약학회지 / v.37, no.5, 1993년, pp.490-498
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한국산 고등균류 만가닥버섯의 항암성분( Studies on Constitutents of the Higher Fungi of Korea : Antitumor Components of the Basidiocarps of Hypsizigus mamoreus )
박성미 (서울대학교 약학대학) 진미림 (서울대학교 약학대학) 김진숙 (서울대학교 약학대학) 최응칠 (서울대학교 약학대학) 김병각 (서울대학교 약학대학)

초 록
To find antitumor components in the hot water extract from the basidiocarps of Hypsizigus mamomus. protein-bound polysaccharides were purified and fractionated by DEAE-cellulose ion exchange column chromatography and Sepharose CL-4B gel filtration chromatography. When a dose of 20 mg/kg/day was injected intraperitoneally into ICR mice. fraction IV of the component showed the highest inhibition ratio of 73.8% against the count of hemolytic plaque forming cells in mice to 3.2 times. when IV was about 30 KD and the fraction was composed of 76.1% polysaccharide and 4.9% protein. The hexosamine was detected in all the fractions, showing that the polysaccharide and protein moieties were bound each other.

Hypsizigus mamoreus; basidiocarps; protein bound polysarccharides; tumor inhibition ratio; hermolytic plaque forming cells

약학회지 / v.37, no.5, 1993년, pp.490-498
pISSN : 0377-9556
UCI :G100:I100-KOI(KISTI1.1003/JNL.JAKO199311919469680)
기사 주제 분류 : 생물학적 제제 및 면역요법제
언어 : 한국어